Title

Dissecting wnt signalling pathways and wnt-sensitive developmental processes through transient misexpression analyses in embryos of Xenopus laevis

Document Type

Article

Publication Date

1993

Publication Title

Development Supplement

Department

Biology

Abstract

We review evidence that Xenopus Wnts (Xwnts) have activities consistent with their hypothesized roles as secreted signalling factors involved in multiple developmental processes. Transient misexpression of different Xwnts has distinct effects upon early development, and upon the formation of tissues in UV-irradiated embryos. Misexpression of Xwnts also has distinct effects on the in vitro differentiation of blastula cap explants. Cellular responses to Xwnt signals include changes in gap junctional permeability, altered responsiveness to growth factors, and possibly changes in cell adhesion.