Title

Single Ion Channel Recordings with CMOS-Anchored Lipid Membranes

Document Type

Article

Publication Date

2013

Publication Title

Nano Letters

Department

Neuroscience

Abstract

We present single-ion-channel recordings performed with biomimetic lipid membranes which are directly attached to the surface of a complementary metal-oxide-semiconductor (CMOS) preamplifier chip. With this system we resolve single-channel currents from several types of bacterial ion channels, including fluctuations of a single alamethicin channel at a bandwidth of 1 MHz which represent the fastest single-ion-channel recordings reported to date. The platform is also used for high resolution alpha-hemolysin nanopore recordings. These results illustrate the high signal fidelity, fine temporal resolution, small geometry, and multiplexed integration which can be achieved, by leveraging integrated semiconductor platforms for advanced ion channel interfaces

Volume

13

Issue

6

pp.

2682-2686

ISSN

1530-6984