EndoGI modulates Notch signaling and axon guidance in Drosophila
Mechanisms of Development
Signaling through the Notch receptor has dramatically different effects depending on cell type and developmental timing. While a myriad of biological systems affected by Notch have been described, the molecular mechanisms by which a generic Notch signal is translated into a cell-type-specific output are less clear. Canonically, the Notch intracellular domain (NICD) translocates into the nucleus upon ligand binding to transcriptionally regulate target genes. In order to generate specificity, therefore, additional factors must exist that modulate NICD
O'Keefe, D.D., B.A. Edgar, and L.J. Saucedo. 2011. "EndoGI modulates Notch signaling and axon guidance in Drosophila". Mechanisms of Development. 128 (1-2): 59-70.