Title

EndoGI modulates Notch signaling and axon guidance in Drosophila

Document Type

Article

Publication Date

2011

Publication Title

Mechanisms of Development

Department

Biology

Abstract

Signaling through the Notch receptor has dramatically different effects depending on cell type and developmental timing. While a myriad of biological systems affected by Notch have been described, the molecular mechanisms by which a generic Notch signal is translated into a cell-type-specific output are less clear. Canonically, the Notch intracellular domain (NICD) translocates into the nucleus upon ligand binding to transcriptionally regulate target genes. In order to generate specificity, therefore, additional factors must exist that modulate NICD

Volume

128

Issue

12

pp.

59-70

ISSN

0925-4773