Schizophrenia is a largely undiscovered disease. Researchers haven't discovered a mechanism for effects and they still do not completely know how it affects the brain. The COMT gene as well as the epigenetic regulation of certain glutaminergic and GABAergic neurotransmitters have been proposed as possible causes for Schizophrenia, but like most research of this disease, it is not proven. The treatment for this disease has gotten better, but there still is not one that does not involve altering the natural processes of the brain.
"The Progression of a Disease: an Overview of Schizophrenia,"
Sound Neuroscience: An Undergraduate Neuroscience Journal: Vol. 1
, Article 14.
Available at: http://soundideas.pugetsound.edu/soundneuroscience/vol1/iss1/14