Forkhead domain family of transcription factors (Foxp) are important in the control of neural stem cell maintenance and differentiation within the developing spinal cord. The aim of the current study is to identify regions of the mouse brain that express FOXP2, FOXP4, and FOXP1 genes at embryonic and post-natal stages. It is hypothesized that the expression pattern in the brain will be similar to that in the spinal cord. Confocal microscopy was used to visualize fluorescent antibody tags on the target proteins. It was found that the FOXP genes are not progressively expressed in the developing brain as they are in the spinal cord; however, the characterization of their expression in the brain could eventually help to determine their functions in brain development and ultimately their purposes in the adult brain.
"Characterization of Foxp Expression in the Embryonic and Neonatal Mouse Brain,"
Sound Neuroscience: An Undergraduate Neuroscience Journal:
2, Article 1.
Available at: http://soundideas.pugetsound.edu/soundneuroscience/vol1/iss2/1