Faculty Advisor
Saucedo, Leslie
Area of Study
Science and Mathematics
Publication Date
Summer 2018
Abstract
Previous research has suggested a connection between oncogenic Ras and the cell’s levels of Reactive Oxygen Species (ROS). The underlying cellular mechanism is not well understood. To investigate this connection, we applied the UAS-GAL4 system in Drosophila melanogaster flies to control the expression of Ras and Keap1, a key redox regulator.2 We expected the activity of Ras to vary with its redox environment and thus impact protein activity downstream of Ras signaling cascades. In monitoring three proteins downstream of Ras—Dcp-1, Akt, and MAPK—we aimed to determine which pathways were impacted by ROS modulation.
Recommended Citation
Andersen, Chris, "Impact of ROS Presence on Oncogenic Ras Activity" (2018). Summer Research. 303.
https://soundideas.pugetsound.edu/summer_research/303
Rights
Publisher
University of Puget Sound
Included in
Biology Commons, Cancer Biology Commons, Cell Biology Commons