Synthesis of 3-aryl substituted benzo[1,2,5]triazepin-4-ones via intramolecular imine formation
3-Aryl substituted benzo[1,2,5]triazepin-4-ones and their pyrido counterparts have been synthesized in five steps from commercially available starting materials. The key step involves base-induced cleavage of trifluoroacetyl-protected hydrazine intermediates and in situ intramolecular imine formation.
Tomaszewski, M.J, L Boisvert, and S Jin. "Synthesis of 3-Aryl Substituted Benzo[1,2,5]triazepin-4-Ones Via Intramolecular Imine Formation." Tetrahedron Letters. 50.13 (2009): 1435-1437. Print.