Novel benzimidazole derivatives as selective CB2 agonists
Bioorganic & Medicinal Chemistry Letters
The preparation and evaluation of a novel class of CB2 agonists based on a benzimidazole moiety are reported. They showed binding affinities up to 1 nM towards the CB2 receptor with partial to full agonist potencies. They also demonstrated good to excellent selectivity (>1000-fold) over the CB1 receptor.
Page?, D, E Balaux, L Boisvert, Z Liu, C Milburn, M Tremblay, Z Wei, S Woo, X Luo, YX Cheng, H Yang, S Srivastava, F Zhou, W Brown, M Tomaszewski, C Walpole, L Hodzic, S St-Onge, C Godbout, D Salois, and K Payza. "Novel Benzimidazole Derivatives As Selective Cb2 Agonists." Bioorganic & Medicinal Chemistry Letters. 18.13 (2008): 3695-700. Print.