A chiral auxiliary cleavable by ring-closing alkene metathesis - Efficient synthesis of chiral nonracemic cycloalkenes
Canadian Journal of Chemistry
p-Menthane-3-carboxaldehyde is a readily available chiral auxiliary used to prepare cycloalkenes and heterocycles bearing a chiral tertiary or quaternary carbon of high enantiomeric purity. The auxiliary is available in both enantiomeric forms and is inexpensive and recyclable. It is cleaved by a ring-closing alkene metathesis reaction directly yielding the cycloalkene.Key words: chiral auxiliary, cleavage reaction, cyclization, ring-closing alkene metathesis, enantioenriched cycloalkenes.
Boisvert, Luc, Francis Beaumier, and Claude Spino. "A Chiral Auxiliary Cleavable by Ring-Closing Alkene Metathesis - Efficient Synthesis of Chiral Nonracemic Cycloalkenes." Canadian Journal of Chemistry. 84.10 (2006): 1290-1293. Print.