Title

Do the different “heteromes” cause genomic shock in newly formed allopolyploids?

Document Type

Article

Publication Date

6-2003

Publication Title

Philosophical Transactions of the Royal Society B: Biological Sciences

Department

Biology

Abstract

Allopolyploidy, the joining of two parental genomes in a polyploid organism with diploid meiosis, is an important mechanism of reticulate evolution. While many successful long–established allopolyploids are known, those formed recently undergo an instability phase whose basis is now being characterized. We describe observations made with the Arabidopsis system that include phenotypic instability, gene silencing and activation, and methylation changes. We present a model based on the epigenetic destabilization of genomic repeats, which in the parents are heterochromatinized and suppressed. We hypothesize that loss of epigenetic suppression of these sequences, here defined as the heterome, results in genomic instability including silencing of single–copy genes.

ISSN

0080-4622

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