Pax3/7 expression coincides with MyoD during chronic skeletal muscle overload
Muscle and Nerve
Paired box (Pax) proteins 3 and 7 are key determinants for embryonic skeletal muscle development by initiating myogenic regulatory factor (MRF) gene expression. We show that Pax3 and 7 participate in adult skeletal muscle plasticity during the initial responses to chronic overload (?7 days) and appear to coordinate MyoD expression, a member of the MRF family of genes. Pax3 and 7 mRNA were higher than control within 12 h after initiation of overload, preceded the increase in MyoD mRNA on day 1, and peaked on day 2. On days 3 and 7, Pax7 mRNA remained higher than control, suggesting that satellite cell self-renewal was occurring. Pax3 and 7 and MyoD protein levels were higher than control on days 2 and 3. These data indicate that Pax3 and 7 coordinate the recapitulation of developmental-like regulatory mechanisms in response to growth-inducing stimuli in adult skeletal muscle, presumably through activation of satellite cells. Muscle Nerve, 2008
Hyatt, Jon-philippe K., Gary E. McCall, Elizabeth M. Kander, Hui Zhong, et al. 2008. "Pax3/7 expression coincides with MyoD during chronic skeletal muscle overload." Muscle & Nerve 38(1): 861-866.