The Role of the IGF-1/Akt/mTOR Pathway on Tibialis Anterior Muscle Hypertrophy During Regeneration in Cardiotoxin-induced Injury in Adult Mice
Area of Study
Science and Mathematics
The purpose of this study was to determine the expression of genes in the IGF-1-mediated pathway involved in protein synthesis and degradation on muscle regeneration after cardiotoxin (CTX)-induced injury, which may be causing muscle hypertrophy. Quantitative Real-Time Polymerase Chain Reaction (qPCR) and western blots were used to quantify expression of degradation and synthesis markers respectively. Absolute and relative tibialis anterior (TA) muscle weights were significantly greater than the respective control after 2-, 3-, and 4-weeks CTX. There were no significant differences in gene expression of atrogin-1, MuRF-1, or myostatin between the CTX-injured and the Control TA muscle at the 2-, 3-, and 4-week time points.
Kasten, Cambria and Kim, Jung A. PhD, "The Role of the IGF-1/Akt/mTOR Pathway on Tibialis Anterior Muscle Hypertrophy During Regeneration in Cardiotoxin-induced Injury in Adult Mice" (2019). Summer Research. 349.
University of Puget Sound
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