Area of Study
Science and Mathematics
This project aims to investigate the role of an enzyme called MMP2 in skeletal muscle hypertrophy after functional overload of the plantaris muscle in wild-type and MMP2 knockout mice. Specifically, we examined the expression of muscle differentiation markers MyoD and myogenin using Quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) in the functionally overloaded plantaris muscle from wild type (WT) and MMP-2 knockout (KO) mice. We hypothesized that the decreased hypertrophic response to FO in MMP-2 KO mice is due to impaired ECM remodeling and impairment of protein synthesis pathways.
Sci/Math Summer Research Scholar
MacIlwaine, Natalie; McCall, Gary; and Kim, Jung, "mRNA Expression of Muscle Differentiation Markers in Wild Type and MMP-2 Knockout Mice After Functional Overload of the Plantaris Muscle" (2021). Summer Research. 397.
University of Puget Sound